GET THE APP

Synthesis, Anti-HIV and Anti-Microbial Activity of Substituted 1-(5-(4-Phenyl)-2-Mercapto-1H-Imidazol-1-Yl)-3-Phenylthiourea Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, Anti-HIV and Anti-Microbial Activity of Substituted 1-(5-(4-Phenyl)-2-Mercapto-1H-Imidazol-1-Yl)-3-Phenylthiourea Derivatives

Author(s): Rohit Singh, Swastika Ganguly

In the current study, a series of five 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea analogs (5a-5e) have been synthesized, characterized by physical (Melting point, Thin Layer Chromatography) and spectral data (IR, 1H-NMR, and Mass spectrometry) and evaluated for their AntiHIV, Antibacterial, Antifungal and Anthelmintic activity with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Compounds 5a and 5b being the most active showed therapeutic index that was 17.5 and 19.9 compared to Zidovudine (AZT) having the Therapeutic Index (TI) 514342.6. On the other hand, it shows an excellent antibacterial, antifungal as well as anthelmintic activity.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry