Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, Anti-HIV and Anti-Microbial Activity of Substituted 1-(5-(4-Phenyl)-2-Mercapto-1H-Imidazol-1-Yl)-3-Phenylthiourea Derivatives

Author(s): Rohit Singh, Swastika Ganguly

In the current study, a series of five 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea analogs (5a-5e) have been synthesized, characterized by physical (Melting point, Thin Layer Chromatography) and spectral data (IR, 1H-NMR, and Mass spectrometry) and evaluated for their AntiHIV, Antibacterial, Antifungal and Anthelmintic activity with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Compounds 5a and 5b being the most active showed therapeutic index that was 17.5 and 19.9 compared to Zidovudine (AZT) having the Therapeutic Index (TI) 514342.6. On the other hand, it shows an excellent antibacterial, antifungal as well as anthelmintic activity.


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