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Synthesis Antimicrobial and Anti-inflammatory Activities of 3,5-Diphenyl-1H-pyrazole Substituted Azepine-5-carboxamide dandeacute;rivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis Antimicrobial and Anti-inflammatory Activities of 3,5-Diphenyl-1H-pyrazole Substituted Azepine-5-carboxamide dérivatives

Author(s): Satyanarayana KVVV, Venkata Swamy Tangeti, Eswar Kumar K

The versatile synthons N-(4-acetylphenyl)-10-methyl-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide (4) and aryl aldehyde with different substituents on aryl group were used as precursors for the synthesis of a series of 10-methyl-N-(4-(5-aryl-1H-pyrazol-3-yl)phenyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide. The anti-microbiological evaluation of were carried out in vitro assays for antifungal, antibacterial and anti-inflammatory activities. Antibacterial, antifungal and anti-inflammatory screening showed that the newly synthesized compounds 5a to 5k and 6a to 6k were display impressive antimicrobial and anti-inflammatory activity.


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