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Synthesis, antimicrobial and antimycobacterial evaluation of star shaped hydrazones derived from 1,3,5-triazine | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, antimicrobial and antimycobacterial evaluation of star shaped hydrazones derived from 1,3,5-triazine

Author(s): Shrinath S. Machakanur, Basavaraj R. Patil, Aishakhanam H. Pathan, Ganesh N. Naik, Shashikala G. Ligade , Kalagouda B. Gudasi

Trisubstituted s-triazine hydrazones [N3C3(-OC6H4-p-CH=N-NH-C(O)-C6H4-p-X)3] (X = H, Br, Cl, F) were prepared in excellent yields by the reaction of p-substituted N’-(4-hydroxy-benzylidene)-hydrazides with cyanuric chloride. The structures were elucidated by elemental analysis, FT-IR, 1H, 13C NMR and MALDI-TOF mass spectrometry. These s-triazine hydrazone derivatives were evaluated for their in vitro antimicrobial and antimycobacterial activity using serial dilution method.


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