Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Synthesis, Anti-microbial Evaluation and Docking Studies of Some Novel Bridged Benzofuran and 1,2,3-Triazole Based Analogues

Author(s): Nagamani Modumpuram, Kishore Kumar Angajala, Sunitha Vianala, Jalapathi Pochampalli, Jayasree D, Shravan Kumar Gunda

A new series of substituted 1-(2-((1H-1,2,3-triazol-4-yl)methoxy)-5-((2-benzoyl-3-methylbenzofuran-5-yl)methyl)phenyl)ethanonederivatives were synthesized by copper(I) catalyzed azide-alkyne cyclo-addition (CuAAC) reaction. All the newly synthesized compounds were characterized by 1H NMR, 13C NMR and mass spectroscopy. The representative analogues were screened in vitro antibacterial and antifungal activity. The newly synthesized compounds were showed significant antibacterial activity and moderate antifungal activity compared to standard drugs ciprofloxacin and nystatin respectively.


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