Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Characterization and Antibacterial Activities of Novel Thieno, Pyrazol Pyridines and Pyrazolopyrimidine Derivatives

Author(s): Hussein SH Mohamed, Mohamed NM Gad, Ali M El-zanaty, Sayed A Ahmed

Series of new heterocyclic compounds, Theinopyridines, Pyrazolopyridines and pyrazolopyrimidines derivatives were obtained by the reaction of sodium salt of 1-(4,5-diphenyl-1H-pyrrol-3-yl)ethanone with aminopyrazole derivatives, cyanothioacetaamide and cyanoacidhydrazide. The obtained compounds were confirmed by spectroscopic analysis such as Infrared Radiation (IR) and Proton Nuclear Magnetic Resonance (1H-NMR) and mass spectra. The newly synthesized compounds screened for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Pyrazolopyridines and Pyrazolopyrimidines showed anti-microbial, anti-bacterial and anti-fungal activities.

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