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Synthesis, Characterization and Antimicrobial Evaluation of Pyrimido Cyclohept[B] Indole Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, Characterization and Antimicrobial Evaluation of Pyrimido Cyclohept[B] Indole Derivatives

Author(s): Ramya V* and Sangeetha V

Some cyclohept[b]indole alkaloids were isolated from natural source and were mostly isolated from Ervatamia, Pandaca and Caulerpa that exhibit antimicrobial, anticancer, and anti-HIV activities. This work describes a strategic approach forthe synthesis ofefficient precursor 2-(4′-methyl)benzylidene-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a)which can obtained by aldol condensation of the 7-methyl-1-oxo-2,3,4,5-tetra-hydrocyclohept[b]indole(1a) with 4-methyl benzaldehyde(2) under basic conditions. Hydroxypyrimido carbazoles were derived by the treatment of 2(4′-methyl)benzylidine-7-methyl-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a) wastreatedwithurea and guanidine nitrate in sodium methoxide under proper condition.


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