Research Article
Synthesis, Characterization and Antimicrobial Evaluation of Pyrimido Cyclohept[B] Indole Derivatives
Author(s): Ramya V* and Sangeetha V
Some cyclohept[b]indole alkaloids were isolated from natural source and were mostly isolated from Ervatamia, Pandaca and Caulerpa that exhibit antimicrobial, anticancer, and anti-HIV activities. This work describes a strategic approach forthe synthesis ofefficient precursor 2-(4′-methyl)benzylidene-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a)which can obtained by aldol condensation of the 7-methyl-1-oxo-2,3,4,5-tetra-hydrocyclohept[b]indole(1a) with 4-methyl benzaldehyde(2) under basic conditions. Hydroxypyrimido carbazoles were derived by the treatment of 2(4′-methyl)benzylidine-7-methyl-1-oxo-3,4,5,10-tetrahydrocyclohept[b]indole(3a) wastreatedwithurea and guanidine nitrate in sodium methoxide under proper condition... Read More»