Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, Characterization, Anthelmintic and Insilico Evaluation of 4,6-Disubstituted Pyrimidine-2-One Derivatives

Author(s): Sudha Rani K, Lakshmi Durga J, Srilatha M, Sravani M, Sunand V, Vinod B

A Series of Bioactive compounds 4,6–Di Phenyl Pyrimidine-2-ol (4a), 4-(3- nitro phenyl)-6-Phenyl-2(1H)-Pyrimidinone (4b), 4-(2-hydroxy phenyl)-6-phenyl pyrimidin-2(1H)-one (4c), 4,[4-(Dimethyl amino) phenyl]-6-Phenyl Pyrimidine-2(1H)-one (4d), 4-(2-chlorophenyl)-6-Phenyl Pyrimidine-2(1H)-one (4e), were Synthesized according to the Literature methods. The Synthesized compounds were characterized by NMR, IR and Mass Spectroscopy. Anthelmintic Activity and Insilico evaluations were carried out for synthesized compounds.


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