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Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterrization and biological evaluation of 2,6-diphenyl-3-(4-(3- phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)phenyl)-2H-1,3,5- oxadiazine-4(3H)-thione

Author(s): Rambabu Nunna , Ramachandran.D, Viral B. Modi, Kirti J.Goswami

4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) prepared by treating benzoic acid hydrazide successively with CS2,- KOH and NH2.NH2,give the nitrogen bridge head fused heteocycles (3) on reacting with N-acetyl-p-Amino benzoic acid followed by hydrolysis. It was on facile condensation reaction with various substituted aromatic aldehydes yields Schiff bases/anils/Azomethines (4a-h). These anils on cyclo- addition reaction with benzoyl isothiocyanate afforded 1,3,5-Oxadiazine (5a-h). These compounds were screened for activities against bacterial and fungal strains.


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