4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol (1) prepared by treating benzoic acid hydrazide successively with CS2,- KOH and NH2.NH2,give the nitrogen bridge head fused heteocycles (3) on reacting with N-acetyl-p-Amino benzoic acid followed by hydrolysis. It was on facile condensation reaction with various substituted aromatic aldehydes yields Schiff bases/anils/Azomethines (4a-h). These anils on cyclo- addition reaction with benzoyl isothiocyanate afforded 1,3,5-Oxadiazine (5a-h). These compounds were screened for activities against bacterial and fungal strains.
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