Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis of 1H-pyrazolo[1, 2-b]phthalazine-5,10-dione derivatives using NiFe2O4 Nanoparticle as a Heterogeneous Catalyst

Author(s): Vijay V Dabholkar, Swapnil K Kurade, Keshav S Badhe

A direct and efficient approach for the preparation of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones has been developed through one pot four component reaction of easily available phthalic anhydride, hydrazine monohydrate, aromatic aldehyde and malononitrile or ethyl acetoacetate catalyzed by nano particulate NiFe2O4, a heterogeneous base catalyst at 55°C. This protocol offers excellent yield of products within short reaction time, easy work up, easy to separate and recyclable catalyst.


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