Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis of Polysubstituted Amino Pyrazole via Multicomponenet Strategy Using NiFe2O4 Nanocatalyst

Author(s): Vijay V Dabholkar, Swapnil K Kurade, Keshav S Badhe, Krishnan Karthik, Shrikant Anpat

A NiFe2O4 nanoparticle found to be excellent catalyst for multicomponent synthesis of 5-amino-1H-pyrazole-4-carbonitrile using substituted aromatic aldehyde, malononitrile and phenyl hydrazine at room temperature. The important features of this process are short reaction time, easy work-up, purification by a non-chromatographic method.

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