GET THE APP

Synthesis of Some Pyrimidine and Fused Pyrimidine Derivatives with Antimicrobial and Anticancer Activities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis of Some Pyrimidine and Fused Pyrimidine Derivatives with Antimicrobial and Anticancer Activities

Author(s): Mohamed A Shaaban, Khalid O Mohamed, Mohamed E Hegazi, Montaser Sh A Shaykoon, Yaseen AMM Elshaier

A new series of pyrimidines and fused pyrimidines derivatives including differently substituted benzylidenes, heterocycles such as pyrazole ring and fused ring systems such as triazolo [4,3-a] pyrimidine, pyrido [2,3-d] pyrimidine and pyramido [4,5-d] pyrimidine systems is reported. The synthetic routes were adopted via formation of substituted pyrimidine core structure in simple and efficient procedures. The chemical structures of new compounds were fully characterized by using complete spectral analyses data. The new compounds were evaluated for their anti-cancer and antimicrobial activities. Among the tested compounds, compounds 7i, 7h and 11c exhibited the best activity against different cancer cell lines. Compounds 8c, 11c and 14b showed potent activity as anti-microbial agents compared to standard drugs.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry