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Synthetic and Pharmacophoric Utility of Quinazoline Motif in Drug Design | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthetic and Pharmacophoric Utility of Quinazoline Motif in Drug Design

Author(s): Prakash Prajapat, Ganpat L Talesara, Shikha Agarwal

Heterocyclic motifs are pervasive in several areas of life sciences. These motifs are performing numerous important functions in drug, agriculture and technology. Nitrogen-containing heterocycle quinazoline motif is the subject of continuous interest in organic synthesis owing to the fact that they occur ubiquitously in biological active multipurpose oriented functional material as well as highly potent pharmaceuticals and agrochemicals. Quinazoline has been a popular heterocycle in pharmaceutical and medicinal chemistry allowing the construction of structurally different molecules with diverse pharmacophoric properties viz. antimicrobial, antimalarial, antiparasitic, anticonvulsant, anticancer, anti-inflammatory antiviral, analgesic, etc. This short communication is an effort to compile the literature of several synthetic approaches and medicinal properties of quinazoline analogues. This review helps in the further development of newer quinazolines for future drug discovery.


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