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TBAI/CS2 Mediated Cleaner, Greener Synthesis and Anticancer Activity of 3-Substituted- (4-Oxo-2-Thioxo-Thiazolidin-5-Ylidene)-Methyl Ethanoates | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

TBAI/CS2 Mediated Cleaner, Greener Synthesis and Anticancer Activity of 3-Substituted- (4-Oxo-2-Thioxo-Thiazolidin-5-Ylidene)-Methyl Ethanoates

Author(s): Nitin Srivastava, Ram Kishore, Namrata Kalia, Jatinder Singh and Devdutt Chaturvedi*

Owing to the key importance of 3- substituted- (4-oxo-2-thioxo-thiazolidin-5- ylidene)-methyl ethanoates in various biological activities, a new greener, cleaner and cheaper method is being put forward here employing primary amines, but-2-yne dioic acid dimethyl ester, CS2 and phase transfer catalyst tetrabutyl ammonium iodide (TBAI) in dimethyl sulphoxide. The synthesized compounds have been found to possess good in-vitro anti-cancer activities against cervical cancer cells, colon cancer cells and brain cancer cells.

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