Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Telmisartan and Hydrochlorothiazide Simultaneous Quantitative Estimation in Bulk and Marketed Tablet Formulation Study by Hptlc- By Stability Indicating Method

Author(s): Rahul Shukla, Vijay Nigam, Shweta

A stability indicating High Performance Thin Layer Chromatography (HPTLC) method is proposed for the simultaneous estimation of Telmisartan and hydrochlorothiazide in bulk and tablet formulation. Well resolved chromatogram was obtained on TLC plates coated with silica gel 60F254 with densitometric detection at 233 nm. Two drugs were satisfactorily resolved with Rf 0.21 ± 0.02 and 0.53 ± 0.02 for Telmisartan and Hydrochlorothiazide respectively. Linearity was found in the range of 0.18-5.76 μg / band (r2 = 0.999) for telmisartan and 0.056-1.6 μg/ band (r2=0.999) for Hydrochlorothiazide. The % recovery for analytes were in the range of 98.5%-101.6% w/w. Drugs were subjected to stress conditions like acid, base, neutral hydrolysis, oxidative, photolytic and thermal stress. Hydrochlorothiazide was found to be more prone to degradation than telmisartan. Both drugs were oxidised fast as compared under other stress conditions. Peak purity has indicated no interference from numerous degradation products formed with the analysis of drugs.


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