GET THE APP

Telmisartan and Hydrochlorothiazide Simultaneous Quantitative Estimation in Bulk and Marketed Tablet Formulation Study by Hptlc- By Stability Indicating Method | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Telmisartan and Hydrochlorothiazide Simultaneous Quantitative Estimation in Bulk and Marketed Tablet Formulation Study by Hptlc- By Stability Indicating Method

Author(s): Rahul Shukla, Vijay Nigam, Shweta

A stability indicating High Performance Thin Layer Chromatography (HPTLC) method is proposed for the simultaneous estimation of Telmisartan and hydrochlorothiazide in bulk and tablet formulation. Well resolved chromatogram was obtained on TLC plates coated with silica gel 60F254 with densitometric detection at 233 nm. Two drugs were satisfactorily resolved with Rf 0.21 ± 0.02 and 0.53 ± 0.02 for Telmisartan and Hydrochlorothiazide respectively. Linearity was found in the range of 0.18-5.76 μg / band (r2 = 0.999) for telmisartan and 0.056-1.6 μg/ band (r2=0.999) for Hydrochlorothiazide. The % recovery for analytes were in the range of 98.5%-101.6% w/w. Drugs were subjected to stress conditions like acid, base, neutral hydrolysis, oxidative, photolytic and thermal stress. Hydrochlorothiazide was found to be more prone to degradation than telmisartan. Both drugs were oxidised fast as compared under other stress conditions. Peak purity has indicated no interference from numerous degradation products formed with the analysis of drugs.


Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry