Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

The In-Silico Screening of Pyrazolo[3,4-E][1,4]Thiazepine Derivatives as Potent Cytotoxic Agents

Author(s): Srikanth A, Hemanth Kumar P, Vijayakumar V, Sudha, Anand A, Sarveswari S

A new series of 1, 4-thiazepinone incorporated pyrazolopyridines has been synthesized using L-proline as a catalyst through multi-component reaction which in turn subjected to the in-silico cytotoxicity studies against various cancer cell lines and almost all the compounds found to show good to moderate activity. Among the tested compounds, compound 4f and 4k are found to have le


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