Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

The Relationship between Blood Counts and Serum Levels of Zinc and Copper in Children with β-thalassemia Living in Najaf Governorate, in Iraq

Author(s): Rasha Shaker Nima, Hannan Ali Ablaa, Hussain Jasem Mohammed

Background: There are elaborate systems in the body that managing and regulating blood and stored levels of trace metals. The Supplement can prevent or decreases the severity of different diseases. While, several drugs altered zinc and copper levels, what can create different diseases.

Aim: To estimate the impact of serum micro-nutrients level; Zinc and copper on blood counts in β-thalassemia patients.

Methods: This analytical cross sectional study involved 108 diagnosed cases of β-thalassemia, (Age 5-15 year) live in the Najaf governorate in Iraq. Anthropometric data and the history therapies, as well as duration of blood transfusion were recorded. Blood samples collected for full blood count and hemoglobin electrophoresis evaluation. Zinc and copper in serum were measured by flame atomic absorption. Ferritin was analyzed by Enzyme-linked Immunosorbent Assay (ELISA) method.

Results: Serum zinc and copper levels reveled variable relations with blood counts and height for age Z-score. There were significant negative correlation between Zn values and height for age Z-score and ferritin levels. While serum copper levels were significantly associated with platelet count, Mean Corpuscular Volume (MCV), Mean Corpuscular Volume (MCH) and White Blood Cell (WBC) count.

Conclusion: The significant correlation of blood zinc level with high for age Z-score and ferritin levels may be pointed that zinc can reduce the complication of β-thalassemia. While an increase in the serum copper level can initiate the development of β-thalassemia syndrome.


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