GET THE APP

Three Dimensional Quantitative Structural├ó┬?┬?Activity Relationship (3D-QSAR) Studies some 3-{4-[3-(2-aryl-phenoxy) butoxy]-phenyl} Propionic acids as novel PPAR ├?┬│/├?┬┤ agonists | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ilbet

s├╝perbetin giri┼č

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Three Dimensional Quantitative Structural├ó┬?┬?Activity Relationship (3D-QSAR) Studies some 3-{4-[3-(2-aryl-phenoxy) butoxy]-phenyl} Propionic acids as novel PPAR ├?┬│/├?┬┤ agonists

Author(s): M. C. Sharma, Smita Sharma, D. V. Kohli, S. C. Chaturvedi

The use of Three Dimensional Quantitative Structure–Activity Relationships, since its advent, has become increasingly helpful in understanding many aspects of biochemical interactions in drug research. This approach was utilized to explain the relationship of structure with biological activity of selective PPAR γ/δ agonists. The enormity of the PPAR γ/δ agonists discovery is reflected in the unprecedented speed at which research laboratories have sought to validate its clinical implications. 3D QSAR study through recently introduced k- Nearest Neighbor Molecular Field Analysis (k-NN MFA) with Step Wise (SW), Simulated Annealing (SA) and Genetic Algorithm (GA) as variable selection methods resulted in eleven statistically significant models for PPAR γ/δ agonists. These models gave a value of q2 as high as 0.7362 for model 1 and value of pred_r2 as high as 0.6985 for model 3.The k-NN MFA contour plots provided further understanding of the relationship between the structural features of PPAR γ/δ agonists derivatives and their activities, which should be applicable to design new, potential PPAR γ/δ agonists.


PDF

rokettube brazzers

paper.io

agar io

wowcappadocia.com
cappadocia-hotels.com
caruscappadocia.com
brothersballoon.com
balloon-rides.net

wormax io