Abstract

To Evaluate the Interaction of Zandopa® Powder and Parkitidin Tablet in Haloperidol Induced Catalepsy Model in Rat

Author(s): Ravi A Vyas and Swati R Dhande*

Herb Drug Interaction (HDIs) is defined as an interaction between herbal medicinal products and allopathic drugs when administered concomitantly. HDIs alter the body’s function pharmacodynamically and pharmacokinetically. The study concerned on herb drug interaction of Zandopa® powder (Mucuna pruriens) and parkitidin tablet (Amantadine Hydrochloride) in haloperidol-induced catalepsy model in rats. The rats were divided into 5 groups namely group I vehicle control (1% Carboxy Methyl Cellulose (CMC)), group II disease control (1% Carboxy Methyl Cellulose (CMC), group III Zandopa® powder (775 mg/kg of body weight), group IV Parkitidin tablet (10 mg/kg of body weight) and group V combination (Zandopa® powder 775 mg/kg and Parkitidin tablet 10 mg/kg of body weight). Behavioral parameters i.e., muscle rigidity and locomotor activity and biochemical parameters i.e., (MDA, CAT and GSH) were evaluated. The result of the study combination group showed significant (p<0.05) improvement in fall off latency and locomotor activity when compared to the disease group. Biochemical parameters i.e., MDA level significant (p<0.05) decrease, GSH level significant (p<0.05) increase and CAT level showed non-significant effect when compared to the disease group, so it may be concluded that the combination group (Zandopa® powder 775 mg/kg and Parkitidin tablet 10 mg/kg of body weight) showed good additive effect and both can be given concomitantly.

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