Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abderrahim El Haib
Departement de Chimie, Faculte des Sciences Appliquees Ait Melloul, Universite IBN ZOHR, N10. BP 6146 Cite Azrou, Ait Melloul, 86150 Agadir, MoroccoPublications
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Research Article
Regioselective synthesis of 1-alkyl-4-nitro-1H-imidazole using 2-methyl-5-nitroimidazole and 4 nitroimidazole as starting reagents
Author(s): Yassine Hakmaoui*, Fatima Asserne, Abderrahim El Haib, Rahhal El Ajlaoui, Said Abouricha and El Mostapha Rakib
In this work, we were able to achieve a total regioselectivity for the alkylation in the N1 position of 2-methyl-5-nitro-1H-imidazole and in the N1 position of 4-nitro-1H-imidazole; it was carried out in different operating condition (base, solvent, temperature…) with different alkylating agents. The structures of the products obtained, they are established by 1H and 13C NMR spectroscopy. In parallel, a computational study it was carried out in accordance with the experimental results obtained (scheme 1). .. Read More»
DOI: 10.4172/0975-413X.14.4.12-16
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Citations : 23677
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