GET THE APP

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Dhanaraju Magharla Dasaratha

Department of Pharmaceutical Technology. GIET School of pharmacy, Rajahmundry, AP, India

Publications

  • Research Article   
    NOVEL CLARITHROMYCIN LOADED SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR AMPLIFICATION OF SOLUBILITY AND ORAL BIOAVAILABILITY
    Author(s): Sundar Vankayala Devendiran*, Vijayalakshmi Rajendran and Dhanaraju Magharla Dasaratha

    SEDDS (self-emulsifying drug delivery system) are of particularly relevant for the production of isotropic mixtures of oil, surfactant, co-surfactant, and drug in order to solve their physicochemical problems. Clarithromycin (CLA), a macrolide, has a 50 percent absolute bioavailability. The goal of this work was to create a liquid SEDDS system for CLA in order to increase solubility by increasing interfacial surface area and thereby boosting absorption. Clarithromycin SEDDS were produced with isopropyl myristate as the oily phase, Cremophor EL, Tween 80, Brij 58 as surfactants, and isopropyl alcohol, isobutanol, and transcutol EL as co-surfactants. Clarithromycin solubility was studied in a variety of vehicles, including isopropyl myristate, Cremophor EL, brij 58, tween 80, isopropyl alcohol, isobutanol, and transcutol RH, with isopropyl myristate yielding around 112.35 mg/ml. Formula.. Read More»
    DOI: 10.4172/0975-413X.15.4.5-13

    Abstract HTML PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry