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Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Kailas W. Shinde

Department of chemistry, Wilson College, Mumbai, India

Publications

  • Research Article   
    Synthesis, characterisation and anti-breast cancer and antibacterial evaluation of novel 2-phenylquinoline amide derivatives
    Author(s): Kailas W. Shinde*

    A series of new class of 2-phenylquinoline amide derivatives (5a-5j) were synthesized from 5-nitroquinoline through multi-step reactions in good to moderate yields. All the compounds were confirmed by spectral characterization viz FT-IR, MS, 1H-NMR and 13C-NMR. All the molecules were evaluated for their anticancer activity against a breast cancer cell line, MDA-MB-231 by MTT assay and antibacterial activity against Grampositive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) using agar well diffusion method. All the compounds exhibited significant anticancer activity as compared to standard cisplatin but not comparable to doxorubicin HCl. Compound 5g exhibited better promising anti-breast cancer activity. Compounds 5d, 5h, 5i and 5j exhibited moderate antibacterial activity against all the tested org.. Read More»
    DOI: 10.4172/0975- 413X.15.5.59-66

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