Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Khouili M

Laboratoire de Chimie Organique & Analytique, Université Sultan Moulay Slimane, Faculté des Sciences et Techniques, Béni-Mellal, Maroc, BP 523, 23000 Béni-Mellal, Maroc, Morocco


  • Research Article   
    Chromatographic Analysis and Cytotoxic Effect of Extracts of Abrus precatorius a Medicinal Plant with Strong Anticancer Potential
    Author(s): Lébri M*, Lagou SM, Tilaoui M, BahiC, Zirihi GN, Coulibaly A, Hafid A, Zyad A and Khouili M

    This paper aims to evaluate the cytotoxic effect of ethanolic extract of Abrus precatorius leaves on the murinmastocytoma cancer cell line (P815), and chromatographic study of aqueous extract as well. The Aqueous extract was obtained by decoction and ethanolic was obtained by maceration. The chromatographic study was carried out on a thin layer and on a chromatographic column. The cytotoxicity was sought by determining the percentage of lysis of cancer cells and the inhibitory concentration 50% (IC50) by the MTT assay. Chromatographic analysis in thin layer with increasing of solvent polarity (Hexane / acetate of ethyl) showed the different spots depending on solvent polarity. The column chromatography allowed separating two fractions. A dose dependent cytotoxic effect of the extract was observed on the cancer cell line (P815). It was observed that the ethanolic extract has the best c.. Read More»

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