GET THE APP

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Monica Kachroo

Department of Chemistry, Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore-27, India

Publications

  • Research Article   
    Synthesis and Docking Studies of Oxazine Derivatives as Anti-inflammatory and Antioxidant Agents
    Author(s): Kalpana Devi* and Monica Kachroo

    A new series of N-(4-{4-(substituted phenyl)-2-[(4-fluro-benzylidene)-amino]-6H-[1,3] oxazine-6-yl}-phenyl)-isonicotiamide were synthesized by reaction of p-amino acetophenone with isonicotinyl chloride to obtain the secondary amides. ClaisenSchmidth condensation reaction with substituted aldehydes led to the formation of corresponding chalcones. These chalcones were cyclized with urea to form oxazine which further reacted with p-fluorobenzaldehyde to form the corresponding Schiff’s bases. All the synthesized compounds were characterized by IR and 1HNMR spectral data, mass spectra and elemental analysis. The synthesized oxazine and Schiff’s bases of oxazine were docked against protein cyclooxygensase target especially selective COX-2. The invitro anti-inflammatory and antioxidant studies of the synthesized compounds were carried out and the results of the do.. Read More»

    Abstract HTML PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry