Mrunalini Kulkarni

Department of Chemistry, Maharshi Dayanand College of Arts, Science and Commerce, Parel, Mumbai, Maharashtra, India

Publications

• Research Article   
  Simultaneous Determination of Metronidazole and Miconazole Nitrate in Pharmaceutical Formulations by RP-HPLC with Greener Solvent
  Author(s): Mrunalini Kulkarni and Pranay More*
  
  The aim of this study was to develop a simple, sensitive, accurate, efficient and reproducible Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) method that maintains stability for the simultaneous determination of Miconazole nitrate and metronidazole in vaginal gel formulations. Using a diode array detector at 210 nm, chromatography was conducted on a Zorbax SB-8 column (150 × 4.6 mm, 3.5 μm) under linear elution with a combination of solvent A (water) and solvent B (isopropyl alcohol) as the mobile phase, including a flow rate of 1.0 mL/min. The linearity of metronidazole and Miconazole nitrate exhibited correlation coefficients of 0.9997 and 0.9995, respectively. The limits of detection and quantification were 0.05 μg/mL and 0.42 μg/mL for metronidazole and 0.16 μg/mL and 1.24 μg/mL for Miconazole nitrate. The technique yielded good results, with r.. Read More»
  DOI: DOI: 10.4172/0975 413X.17.2.683-691

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