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Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

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Neeraj Agarwal

Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut 250005, India

Publications

  • Research Article   
    Quantitative Structure-Activity Relationship and Molecular Modeling Studies on a series of chiral tetrahydronaphthalene-fused spirooxindole as CDK4 inhibitor against Glioblastoma
    Author(s): Anjali Sharma and Neeraj Agarwal*

    Cyclin Dependent Kinase 4(CDK4) is responsible for the progression of cell cycle at G1-S phase. CDK inhibitor alters the cell cycle that will inhibit cancer cell formation. Spirooxindole derivative targets p53-MDM2 interaction that inhibits CDK4 protein which results in inhibition of cell cycle. Spirooxindole is a unique three- dimensional scaffold that was first isolated from Rubiaceae and Apocynaceae plants. Spriooxindole is a promising drug through many years which can be used to treat an array of diseases such as cancer, analgesic, mental disorder, bacterial and viral infection. From past decade spirooxindole became a huge topic of interest in bio medicinal field due to its multipotentability. In our present work, we have performed QSAR (Quantitative Structure-Activity Relationship) and Molecular modeling studies on a series of chiral tetrahydronaphthalene-fused spirooxindole, res.. Read More»

    Abstract PDF

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