Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Neeraj Agarwal

Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut 250005, India


  • Research Article   
    Quantitative Structure-Activity Relationship and Molecular Modeling Studies on a series of chiral tetrahydronaphthalene-fused spirooxindole as CDK4 inhibitor against Glioblastoma
    Author(s): Anjali Sharma and Neeraj Agarwal*

    Cyclin Dependent Kinase 4(CDK4) is responsible for the progression of cell cycle at G1-S phase. CDK inhibitor alters the cell cycle that will inhibit cancer cell formation. Spirooxindole derivative targets p53-MDM2 interaction that inhibits CDK4 protein which results in inhibition of cell cycle. Spirooxindole is a unique three- dimensional scaffold that was first isolated from Rubiaceae and Apocynaceae plants. Spriooxindole is a promising drug through many years which can be used to treat an array of diseases such as cancer, analgesic, mental disorder, bacterial and viral infection. From past decade spirooxindole became a huge topic of interest in bio medicinal field due to its multipotentability. In our present work, we have performed QSAR (Quantitative Structure-Activity Relationship) and Molecular modeling studies on a series of chiral tetrahydronaphthalene-fused spirooxindole, res.. Read More»

    Abstract PDF

rokettube brazzers

agar io

wormax io

Elektronik Sigara