Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Oyedeji KO
Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, NigeriaPublications
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Research
OVARIAN AND UTERINE GENES TRANSCRIPTIONAL RESPONSES TO ARTESUNATE IN FEMALE WISTAR RATS
Author(s): Oyedeji KO*
Background: This research was designed to investigate ovarian and uterine gene transcriptional responses to artesunate in female rats. Materials and Methods: Female rodents (120 – 140 g) numbering ten were designated for this study. Artesunate (1.43 mg/kg) was given by gavage to the rodents for 50 days. The method of RT-PCR was employed to investigate the expressions of p53, Bcl-2, SOD, aromatase and IL-1β in the ovaries and uteri. Histopathological analyses of the uteri and ovaries were also done. Graphics were generated as average +/- SEM with Graph-pad Prism (version 8.0). Results: The p53 and aromatase expressions were significantly (p<0.05) down-regulated, while the Bcl-2 and IL-1β expressions were upregulated significantly (p<0.05) in the artesunate treated rats’ ovaries relative to their controls. In addition, the p53, Bcl-2, SOD and IL-1β expre.. Read More»
DOI: 10.4172/0975-413X.15.5.95-101
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Citations : 25868
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