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Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

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Shivaji M Koshti

Department of Chemistry, S.S.V.P.S. L.K. Dr. P.R. Ghogrey Science College, Dhule, Maharashtra, India

Publications

  • Research Article   
    Synthesis and Characterization of Prodrugs of Sulfonamides as an Azo Derivatives of Carvacrol
    Author(s): Shivaji M Koshti*, Prashant A Patil, Chetan B Patil and Anil S Patil

    In the present work our goal was to explore the prodrug approach study especially for colon targeting antibacterial agents. We choose the sulfonamides as an antibacterial agent for colon targeting treatments. For this purpose sulfonamides were coupled to carvacrol through azo compound formation. The newly synthesized azo compounds were characterized by spectral techniques such as Infrared (IR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 Nuclear Magnetic Resonance (13C-NMR). The drug released study of the parent compound was done by in vitro enzyme degradation by using azoreductase enzyme which was secreted by pseudomonas aeruginosa bacterium. Carvacrol and its derivatives were known show remarkable biological activity such as antimicrobial, antitumor, antimutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiog.. Read More»

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