Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
AN OVERVIEW AND IN VITRO EVALUATION OF EFFERVESCENT TABLETS OF LORNOXICAM WITH ANTACIDS
Author(s): Aishwarya HiremathObjective: The objective of this study was to mask the bitterness of lornoxicam by inclusion complex method using β cyclodextrin (β CD), to prepare lornoxicam effervescent tablets with antacids by wet granulation method using citric acid, tartaric acid with sodium bicarbonate as effervescent mixture, which is useful to neutralize the acid that may be occurred due to the co-administration of lornoxicam and to compare the in vitro drug release and Acid Neutralizing Capacity (ANC) of tablets of optimized batch with marketed products. Methods: Authentication of lornoxicam was done by FTIR and DSC analysis. The spectral interference of the excipients at analytical wavelength of lornoxicam was studied using UV method. Prepared tablets of lornoxicam then subjected to evaluation of post compression parameters such as thickness and diameter, wetting time, weight variation, hardness, friability, disintegration, dissolution and Acid Neutralizing Capacity (ANC). Drug release profile and ANC of the tablets of optimized batch F-9 were compared with that of the marketed products, further studied for their reproducibility and stability. Results: FTIR and DSC analysis revealed that the received drug was pure lornoxicam. The excipients were showing no absorbance at analytical wavelength of lornoxicam (289.20 nm). The tablets of all the batches were pass the post compression parameters. The tablets of optimized batch F-9 were able to produce release of 100% drug within 5 min with 12.65 ± 0.160 mEq of ANC. The tablets were found to be reproducible and stable after stability studies. Conclusion: Effervescent tablets of lornoxicam with antacids can be efficiently and successfully formulated by wet granulation method with addition of superdisintegrant. The prepared tablets of lornoxicam with sodium saccharin can be chewed and alternatively used as fast dissolving tablets, as it undergoes disintegration within 40 seconds and increases patient compliance, in addition they were able to produce faster dissolution and better ANC than that of the marketed products.
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