Research Article
An Overview and in vitro Evaluation of Effervescent Tablets of Lornoxicam with Antacids
Author(s): Aishwarya Hiremath*
Objective: The objective of this study was to mask the bitterness of lornoxicam by inclusion complex method using β cyclodextrin (β CD), to prepare lornoxicam effervescent tablets with antacids by wet granulation method using citric acid, tartaric acid with sodium bicarbonate as effervescent mixture, which is useful to neutralize the acid that may be occurred due to the co-administration of lornoxicam and to compare the in vitro drug release and Acid Neutralizing Capacity (ANC) of tablets of optimized batch with marketed products.
Methods: Authentication of lornoxicam was done by FTIR and DSC analysis. The spectral interference of the excipients at analytical wavelength of lornoxicam was studied using UV method. Prepared tablets of lornoxicam then subjected to evaluation of post compression parameters such as thickness and diameter.. Read More»