Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Design, Synthesis and Molecular Modeling of New 1,3,5-Triazine Derivatives as Anticancer Agents

Author(s): Marwa I. Serag*, Rania M. Gomaa, Mohammed A.M. Massoud and Hassan M. Eisa

A new series of 1,3,5-triazine analogues were designed, synthesized and in vitro screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines. Compound 6 the most active member in this study, showing effectiveness toward numerous cell lines belonging to different tumor cell lines that reach to 60.13% inhibition in renal cancer (CAKI-1) cell line, also it has good inhibitory activity against PI3Kγ (IC50=6.90 μM) closer activity to reference wortmannin (IC50=3.19 μM). Molecular docking reveal that compound 6 occupied the same pocket of the active site of PI3Kγ and these, consistent with biological results.

Full-Text PDF

bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan