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Design, Synthesis and Molecular Modeling of New 1,3,5-Triazine Derivatives as Anticancer Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design, Synthesis and Molecular Modeling of New 1,3,5-Triazine Derivatives as Anticancer Agents

Author(s): Marwa I. Serag*, Rania M. Gomaa, Mohammed A.M. Massoud and Hassan M. Eisa

A new series of 1,3,5-triazine analogues were designed, synthesized and in vitro screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines. Compound 6 the most active member in this study, showing effectiveness toward numerous cell lines belonging to different tumor cell lines that reach to 60.13% inhibition in renal cancer (CAKI-1) cell line, also it has good inhibitory activity against PI3Kγ (IC50=6.90 μM) closer activity to reference wortmannin (IC50=3.19 μM). Molecular docking reveal that compound 6 occupied the same pocket of the active site of PI3Kγ and these, consistent with biological results.


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