Synthesis of Substituted Phenothiazines derivatives, Antioxidant, P-Glycoprotein, Cyp Enzyme Activity, HIA and BBB Prediction | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Synthesis of Substituted Phenothiazines derivatives, Antioxidant, P-Glycoprotein, Cyp Enzyme Activity, HIA and BBB Prediction

Author(s): Mahesh K Gaidhane, Ajay M Ghatole*, Meghasham N Narule, Pravin K Gaidhane, Kushal R lanjewar and Gunwant P Gadekar

As of late, there is an enormous increment of medication safe pathogens, prompting the plan and advancement of more current antibacterial specialists. Different epic subbed phenothiazines derivatives have arranged to concentrate based on pharmacological exercises in drugs revelation. Phenothiazine derivatives subbed in the 2, 3 and 4 positions have a place with a major gathering of tricyclic aromatic combinations. They are in broad use in psychiatry as tranquillizers and neuroleptics. Because of their trademark structure, they show numerous important scientific properties. A short easy synthesis of 8- [2/-(3//, 5//- dimethyl-4//- ethoxy carbonyl pyrrolyl) hydrazine] subbed phenothiazines (5a-j) from 2-arylaminbenzal-2-(3',5'-dimethyl-4'-ethoxycarbonyl pyrrole) hydrazines (4) in the imminence of sulfur and iodine. These combinations show antibacterial and antifungal drills when contrasted and standard drug Norfloxacin and Griseofulvine against Bacterial cultures, for example, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus Vulgaris and fungal cultures, such as Aspergillus niger and Candida albicans. And also, these compounds screened for their antioxidant activity. The synthesized compounds characterized by FTIR, 1H NMR, elemental and chemical properties. The modern Swiss ADME web tool that stretches free admittance to a pool of hasty yet solid clarifying models for physicochemical properties, pharmacokinetics, and therapeutic science.

Full-Text PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry