Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Gunwant P Gadekar
Dhote Bandhu Science College, Department of Zoology, Gondia, IndiaPublications
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Research Article
Synthesis of Substituted Phenothiazines derivatives, Antioxidant, P-Glycoprotein, Cyp Enzyme Activity, HIA and BBB Prediction
Author(s): Mahesh K Gaidhane, Ajay M Ghatole*, Meghasham N Narule, Pravin K Gaidhane, Kushal R lanjewar and Gunwant P Gadekar
As of late, there is an enormous increment of medication safe pathogens, prompting the plan and advancement of more current antibacterial specialists. Different epic subbed phenothiazines derivatives have arranged to concentrate based on pharmacological exercises in drugs revelation. Phenothiazine derivatives subbed in the 2, 3 and 4 positions have a place with a major gathering of tricyclic aromatic combinations. They are in broad use in psychiatry as tranquillizers and neuroleptics. Because of their trademark structure, they show numerous important scientific properties. A short easy synthesis of 8- [2/-(3//, 5//- dimethyl-4//- ethoxy carbonyl pyrrolyl) hydrazine] subbed phenothiazines (5a-j) from 2-arylaminbenzal-2-(3',5'-dimethyl-4'-ethoxycarbonyl pyrrole) hydrazines (4) in the imminence of sulfur and iodine. These combinations show antibacterial and antifungal dri.. Read More»
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