Ajay M Ghatole

Dhote Bandhu Science College, Department of Chemistry, Gondia, India

Publications

• Research Article   
  Synthesis of Substituted Phenothiazines derivatives, Antioxidant, P-Glycoprotein, Cyp Enzyme Activity, HIA and BBB Prediction
  Author(s): Mahesh K Gaidhane, Ajay M Ghatole*, Meghasham N Narule, Pravin K Gaidhane, Kushal R lanjewar and Gunwant P Gadekar
  
  As of late, there is an enormous increment of medication safe pathogens, prompting the plan and advancement of more current antibacterial specialists. Different epic subbed phenothiazines derivatives have arranged to concentrate based on pharmacological exercises in drugs revelation. Phenothiazine derivatives subbed in the 2, 3 and 4 positions have a place with a major gathering of tricyclic aromatic combinations. They are in broad use in psychiatry as tranquillizers and neuroleptics. Because of their trademark structure, they show numerous important scientific properties. A short easy synthesis of 8- [2/-(3//, 5//- dimethyl-4//- ethoxy carbonyl pyrrolyl) hydrazine] subbed phenothiazines (5a-j) from 2-arylaminbenzal-2-(3',5'-dimethyl-4'-ethoxycarbonyl pyrrole) hydrazines (4) in the imminence of sulfur and iodine. These combinations show antibacterial and antifungal dri.. Read More»
  

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