Adarsh A

Department of Pharmaceutical Chemistry, Shri Sharanabasaveshwar College of Pharmacy, Vijayapur, India

Publications

• Research Article   
  A Review on the Medicinal Significance of Nitrogen-Containing Heterocycles: From Natural Products to FDA-Approved Drugs
  Author(s): Mahesh Parit*, Shrisail bellad, Shreekant Biradar, Smeta P, Suchitra T and Adarsh A
  
  Heterocyclic chemistry, particularly involving N-heterocycles, is a cornerstone of modern organic chemistry due to its wide-ranging applications in medicine, agriculture and industry. N-heterocycles are crucial components of numerous biologically vital substances and are prominent scaffolds in US-FDA-approved drugs and energetic materials, underscoring their significant role in enhancing human life quality. This review highlights the importance of N-heterocycles, showcasing their presence in natural compounds like purines, pyrimidines, amino acids and alkaloids and their historical use as medicines such as antibiotics and antimalarials. A key aspect of N-heterocycles in drug discovery is their ability to act as bioisosteres, enabling structural modifications that improve efficacy, selectivity and pharmacokinetic properties of lead compounds. Examples such as the bioisosteric replaceme.. Read More»
  

  Abstract PDF