Akkamma Hanumappa Godihal

P. G. Department of Pharmaceutical Chemistry, S. J. M. College of Pharmacy, NH4-Bypass, SJMIT Campus, Chitradurga, Karnataka, India

Publications

• Research Article   
  Synthesis, Characterization and Anthelmintic Activity of New N-Substituted 1,2,4-Triazole Derivatives
  Author(s): Pavitra Anant Hedge*, Akkamma Hanumappa Godihal, Vijay Kumar Miralagatti Mathada Jagatageri and Basavaraja Harti Shivappa
  
  The compound 2-amino-3,5-dibromobenzohydrazide was synthesized by dissolving equimolar proportions of methyl-2-amino-3,5-dibenzoate and hydrazine hydrate in water and refluxed for 6 hours. The above compound and carbon disulphide was dissolved in alcoholic potassium hydroxide and refluxed for 4 hours, then poured in to ice-cold water and obtained potassium 2-(2-amino-3,5-dibromobenzoyl) hydrazine-1-carbodithionate. The obtained product was further treated with different functional groups such as isoniazide, 2-amino-4,6-dibromo benozoic acid hydrazide, phenyl hydrazine and hydrazine hydrate in 5ml of water and refluxed for 5 to 6 hours until the evolution of H2S ceases. The reaction mixtures were poured into ice-cold water, acidified with dil HCl. The obtained product was filtered, dried and recrystallized by using hot water. The lead compounds were characterized by melting point, TLC,.. Read More»
  

  Abstract PDF