Pavitra Anant Hedge

P. G. Department of Pharmaceutical Chemistry, S. J. M. College of Pharmacy, NH4-Bypass, SJMIT Campus, Chitradurga, Karnataka, India

Publications

• Research Article   
  Synthesis, Characterization and Anthelmintic Activity of New N-Substituted 1,2,4-Triazole Derivatives
  Author(s): Pavitra Anant Hedge*, Akkamma Hanumappa Godihal, Vijay Kumar Miralagatti Mathada Jagatageri and Basavaraja Harti Shivappa
  
  The compound 2-amino-3,5-dibromobenzohydrazide was synthesized by dissolving equimolar proportions of methyl-2-amino-3,5-dibenzoate and hydrazine hydrate in water and refluxed for 6 hours. The above compound and carbon disulphide was dissolved in alcoholic potassium hydroxide and refluxed for 4 hours, then poured in to ice-cold water and obtained potassium 2-(2-amino-3,5-dibromobenzoyl) hydrazine-1-carbodithionate. The obtained product was further treated with different functional groups such as isoniazide, 2-amino-4,6-dibromo benozoic acid hydrazide, phenyl hydrazine and hydrazine hydrate in 5ml of water and refluxed for 5 to 6 hours until the evolution of H2S ceases. The reaction mixtures were poured into ice-cold water, acidified with dil HCl. The obtained product was filtered, dried and recrystallized by using hot water. The lead compounds were characterized by melting point, TLC,.. Read More»
  DOI: DOI: 10.4172/0975 413X.17.2.676-682

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