Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Anekar VP

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Vidyanagar, Karad, Dist.: Satara Pin- 415124, Maharashtra, India


  • Research   
    Development of Stability Indicating Assay Method for Estimation of Olmesartan Medoxomil and Chlorthalidone in Its Combined Dosage Form
    Author(s): Anekar VP*, Charde MS and Chakole RD

    Performance liquid chromatographic method was developed for estimation of two Anti-hypertensive drugs, Olmesartan medoxomil and Chlorthalidone. The separation of both the drugs was achieved on Phenomenex kinetex XB C-18 column (150 mm X 4.6 mm , 5μ particle size) using mobile phase Acetonitrile : 0.1% TFA Water (45:55v/v). The flow rate was 1 ml/ minute with run time 10 minutes and detection was done at 235 nm. The retention time of Olmesartan medoxomil and for Chlorthalidone was 2.15 min. and 1.71 min. respectively. The linearity of the method was evaluated at a range of 50 to 150 μg/ml and 31.25 to 93.75 μg/ml for Olmesartan medoxomil and Chlorthalidone respectively. The Correlation Coefficient of Olmesartan medoxomil and Chlorthalidone were 0.999 each. Precision studies were carried out and %RSD of peak areas of Olmesartan medoxomil and Chlorthalidone was about 0.051 and 0.. Read More»
    DOI: 10.4172/0975-413X.15.4.14-23

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