Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Asif Ali

Faculty of Pharmacy, IFTM University, Lodhipur, Moradabad (UP) 244001, India


  • Research Article   
    Synthesis and Anticonvulsant Activity of Thiadiazoles Derivatives
    Author(s): Shweta Verma* and Asif Ali

    Background: The derivatives of Thiadiazoles coupled with various benzaldehyde were synthesized. The synthesized derivatives were evaluated for different physicochemical parameters along with Log P values using different software programs to discover its ability to cross the blood brain barrier. The pharmacological activities such as anticonvulsant activity was evaluated by using PTZ method. Objective: The new Thiadiazole derivatives were synthesized and assessed for different properties to predict its CNS activity. Thiosemicarbazide was used as a starting material which undergoes cyclization and then bromination to form the intermediate (C). The amino group of intermediates was allowed to react with different benzaldehydes to form the final product (D1-D5). The derivatives were evaluated for the anticonvulsant activity by using .. Read More»
    DOI: 10.4172/0975-413X.14.5.34-39

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