Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Basavaraj Hiremath
Department of Chemistry, S. S. Margol Degree College, Shahabad – 585 228, Karnataka, IndiaPublications
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Research Article
Synthesis of Cefixime Nanoparticles an Attempt to Enhance Their Development and Validation of Spectrophotometric Methods for the Determination of Pharmaceutical Forms
Author(s): Basavaraj Hiremath*, Nagesh Gunavanthrao Yernale and B.H.M. Mruthyunjayaswamy
Cefixime nanoparticles were prepared by anti-solvent precipitation with syringe pump (APSP) method. Two simple and sensitive spectrophotometric methods I and II for the analysis of cefixime nanoparticles in either pure form or their pharmaceutical formulations are described. Method I is based on the oxidation of the drug with ferric ion succeed by complex development reaction with 1, 10-phenanthroline (1, 10-PTL) to obtain orange-red colored chromogen shows λmax at 510 nm also the method II on the reaction between diazotized drug with diphenylamine (DPA) in neutral medium to yield a pink-colored product which has λmax at 512 nm. The products are unchanging for more than 10 and 4 hrs respectively. Common excipients used as additives in pharmaceutical dosage do not impede the proposed methods. Thus the proposed methods proved to be easy, low cost,.. Read More»