Ethanolic Leaf Extract of Gongronema Latifolium Prevents Depletion of Nitric Oxide and Anti-Oxidants Levels in Streptozotocin Induced Diabetic Rats.
Author(s): Gabriel O Ujong*, Justin A Beshel, Idara Asuquo Okon and Daniel D Owu
Lipid peroxidation is a major disorder that disrupts cellular integrity, resulting in many pathological conditions. This work was designed to evaluate the effect of ethanolic leaf extract of Gongronema latifolium (GL) on nitric oxide, anti-oxidants (SOD, total anti-oxidant capacity) and lipid peroxidation product (MDA) in Streptozotocin-induced diabetic rats. 40 Wistar rats of both sexes (150g-200g) were divided into 5 groups (n=8). Group 1 (control) received 1mL normal saline orally. Group 2 (GL) received 200 mg/kg b.wt. Of GL orally. Group 3 (DM) received 65mg/kg b.wt. of streptozotocin (STZ) i.p. for two days with an interval of one day in between. Group 4 (DM+GL) received 65mg/kg b.wt. Of STZ + 200 mg/kg GL o.p. Group 5 (DM + Insulin) received 65mg/kg bw of STZ insulin (s.c.). Animals with blood glucose above 200mg/dL were declared diabetic. The regiment lasted for 28days. The.. Read More»