Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Lokanatha Rai KM
Department of Studies in Chemistry, University of Mysore, Karnataka, IndiaPublications
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Research Article
Synthesis, Characterization and Biological Activity of Novel Podophyllotoxin Bearing Pyrimidine Moieties
Author(s): Paniraj AS, Sowmya PT* and Lokanatha Rai KM
Podophyllotoxin, a naturally occurring aryl tetralin-type lignan obtained from Podophyllin, an ethanolic extract of Podophyllum peltatum L.(syn.P.hexandnum Royle), exhibits marked biological activity as strong antineoplastic drugs and antiviral agents. Chemical transformations performed on podophyllotoxin resulted in analogs which also display potent cytotoxic, antiviral, and immunosuppressive activities. At present, ten novel compounds of podophyllotoxin bearing pyrimidine moieties were synthesized and characterized by 1H and 13C-NMR, elemental analysis, and Mass spectroscopy. All the synthesized compounds were tested for antimicrobial activities... Read More»
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