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Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Madhuri Baghel

Department of Pharmaceutical Sciences, Apollo College of Pharmacy, Anjora, India

Publications

  • Research Article   
    Exploring the Potential Flavonoids as an Anti-Rheumatoid Arthritis Agent: An In silico Studies
    Author(s): Abhilasha Singh, Sharmistha Banerjee, Surada Prakash Rao, Ashish Majumdar and Madhuri Baghel*

    Rheumatoid arthritis is an autoimmune disease which causes systemic complications, disability and even death. Its pathophysiology involves chronic inflammation of synovial membrane. New molecules in the biologic pathway have been discovered and are considered new target for experiments. In this experiment 100 flavonoids showing anti-inflammatory activities in different studies were evaluated using in silico approach to get the best possible lead. Orientin (IFD score: 640.28) and leucocyanidin (IFD score: 638.22) showed highest binding affinity with protein 4K6Z, while vitexin (IFD score: 622.21) and hyperoside (IFD score: 623.55) showed highest binding affinity with protein 4G1W among the set of flavonoids taken. To support the results of this investigation, leucocyanidin and orientin could be investigated further for the treatment of rheumatoid arthritis th.. Read More»
    DOI: 10.4172/0975-413X.16.1.204-210

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