Magdy AH Zahran

Chemistry Department, Menoufia University, Egypt

Publications

• Research Article   
  Design, Synthesis, Cytotoxicity, Physicochemical and In Vivo Studies of New Thalidomide Dithiocarbamate Analogs as Anticancer
  Author(s): Magdy AH Zahran*, Ayman R Awad, Ahmed BM Mehany and Roba Talaat
  
  Novel thalidomide dithiocarbamate analogs were synthesized in good yield. A two-step synthesis was utilized to obtain the new thalidomide dithiocarbamate analogs by reaction of thalidomide with 1,2 dichloroethane or 1,3 dichloropropane producing chloroethyl thalidomide 2 or chloropropyl thalidomide 3 compounds respectively, which reacts with Sodium diethyl dithiocarbamate to afford thalidomide dithiocarbamate 4 or 5.   The chemical structures of all synthesized compounds were elucidated on the basis of their spectral IR, 1H NMR, 13C NMR, Mass spectroscopy and elemental analysis. The anticancer nature of thalidomide and thalidomide analogs 2-5 was evaluated by screening the in vitro activity on three human cancer cell lines; human lung cancer cells (A-549), human liver cancer cells (HEGP-2) and human breast cancer cells (MCF-7). Also the in vivo a.. Read More»
  

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