GET THE APP

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Roba Talaat

Molecular Biology, University of Sadat City, Egypt

Publications

  • Research Article   
    Design, Synthesis, Cytotoxicity, Physicochemical and In Vivo Studies of New Thalidomide Dithiocarbamate Analogs as Anticancer
    Author(s): Magdy AH Zahran*, Ayman R Awad, Ahmed BM Mehany and Roba Talaat

    Novel thalidomide dithiocarbamate analogs were synthesized in good yield. A two-step synthesis was utilized to obtain the new thalidomide dithiocarbamate analogs by reaction of thalidomide with 1,2 dichloroethane or 1,3 dichloropropane producing chloroethyl thalidomide 2 or chloropropyl thalidomide 3 compounds respectively, which reacts with Sodium diethyl dithiocarbamate to afford thalidomide dithiocarbamate 4 or 5.   The chemical structures of all synthesized compounds were elucidated on the basis of their spectral IR, 1H NMR, 13C NMR, Mass spectroscopy and elemental analysis. The anticancer nature of thalidomide and thalidomide analogs 2-5 was evaluated by screening the in vitro activity on three human cancer cell lines; human lung cancer cells (A-549), human liver cancer cells (HEGP-2) and human breast cancer cells (MCF-7). Also the in vivo a.. Read More»

    Abstract HTML PDF

rokettube brazzers

paper.io

agar io

wowcappadocia.com
cappadocia-hotels.com
balloon-rides.net

wormax io

Smok
Elektronik Sigara