Navnath B. Shinde

Publications

• Research Article   
  Evaluation of Antimicrobial and Antifungal Properties of New Chrysene-Phenothiazine Derivatives
  Author(s): Alpesh T. Shiyani*, Suranjana V. Mayani and Navnath B. Shinde
  
  A novel series of Chrysene-Phenothiazine derivatives was synthesized via the Buchwald-Hartwig C-N coupling reaction using 6-bromochrysene and substituted phenothiazine derivatives. The reaction employed palladium catalysis under inert conditions with appropriate ligands and bases to achieve efficient N-arylation at the phenothiazine nitrogen. This strategy enabled the formation of C-N bonds between the polyaromatic chrysene core and electronically modified phenothiazine units, providing structurally diverse heterocyclic hybrids. All compounds were purified and characterized by ¹H NMR, ¹³C NMR and mass spectrometry to confirm the desired molecular architecture. Preliminary antimicrobial and antifungal screening was performed using the agar well diffusion method, indicating that halogenated analogues displayed better activity profiles. Overall, this work demonstrates the .. Read More»
  

  Abstract PDF