Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Neelam Khan

Amaltas Institute of Pharmacy, Amaltas University, Dewas (M.P.), India


  • Research Article   
    A Comparative QSAR Study on Alkyl and Alkoxy Pyrazolo [1, 5-C] Quinazoline-2- Carboxylates as NMDA/Glycine And AMPA Receptor Antagonists
    Author(s): Neelam Khan* and Javed Khan Pathan

    A Quantitative Structural Relationship study had been performed on Alkyl Alkoxy Pyrazole [1, 5-c] quinazoline-2-carboxylate by using multiple linear regression to identify descriptors, which are actually focusing towards the biological activity. The best predictive QSAR model derived and validated in order to Glutamate receptor models by using a combination of different physicochemical parameters such as steric, electronic and topological. The final QSAR model shows a good predictivity and statistical validation respectively as a NMDA receptor final model had Correlation Coefficient r = 0.928, Square Correlation Coefficient r2 = 0.806, Cross validation Coefficient Q2LOO = 0.685, adjusted correlation coefficient R2adj =0.821, predicted root mean squared error RMSEpred =0.352, predictive residual sum of square S press = 0.352 and st.. Read More»
    DOI: 10.4172/0975-413X.15.3.5-15

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