Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Ocloo A
Pharmacology Department, Centre for Plant Medicine Research, Mampong-Akwapim, GhanaPublications
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Research Article
Analgesic, Anti-Inflammatory and Anti-Oxidant Activities of Clausena anisata leaf and Stem Extracts and Quantitative and Qualitative Phytochemical Analysis of their Contents
Author(s): Kumatia EK*, Ayertey F, Appiah AA and Ocloo A
Clausena anisata is a medicinal plant use to treat diseases including inflammatory, pain and oxidative stress conditions. Nonetheless, these activities have not been evaluated for its stem. This study aimed to evaluate and compared analgesic, anti-inflammatory and anti-oxidant activities of ethanol extracts of leaf (CLE) and stem (CSE) of C. anisata. Anti-inflammatory and anti-oxidant activities were assessed by carrageenan induced paw edema and DPPH free radical scavenging assays respectively. Hot plate and writhing assays were used to test the analgesic activity. Total phenolics and flavonoids were quantified using UV-Vis spectrophotometry methods. CLE and CSE produced (p<0.05) dose-depended anti-inflammatory activity (76.35-85.83%) comparable to that of indomethacin (78.26%) and (p< 0.05) analgesic activity in the writhing assay. The extracts also produce (p<0.000.. Read More»