Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Rao SM

APL Research Centre (A Division of Aurobindo Pharma Limited), Hyderabad-500072, Telangana, India


  • Research Article   
    UPLC Method for the Quantification of Elvitegravir, Cobicistat, Emtricitabine and Tenofovir Disoproxil Fumarate in Tablets Using OGD Reference Dissolution Medium
    Author(s): Vittal SP, Rao SM and Ramakrishna K*

    The current paper discuss about strategic development and validation activity performed for quantification of Elvitegravir (EL), Cobicistat (CO), Emtricitabine (EM) and Tenofovir Disoproxil fumarate (TDF) in a combination drug product using Office of Generic drugs (OGD) recommended Dissolution medium. Ultra Performance Liquid Chromatographic (UPLC) technique method was chosen and developed a method with a run time of four minutes. Mobile phase A consists of 0.1% perchloric acid and Mobile phase B consists of Acetonitrile. Gradient elution technique was opted with an optimized flow rate of 0.3 ml per minutes. Acquity UPLC BEHC18 (100 mm × 2.1 mm ID), 1.7ï?­ particle size column is finalized for testing purpose with a detection wavelength of 260 nm. Typical retention times observed for EM, TDF, CO and EL are 0.89, 1.42, 2.01 and 2.77 mi.. Read More»

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