Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Siva Rama Koti I

Department of Chemistry, Ceturion University of Technology and Management, Parlakhimundi, Odisha - 761211, India


  • Research Article   
    Spectrophotometric determination of Darunavir using NQS and Brucine meta periodate
    Author(s): Acharyulu MLN*, Mohana Rao PVSR and Siva Rama Koti I

    Two simple and sensitive spectrophotometric methods (A and B) for the assay of Darunavir (DNV), in pure and pharmaceutical formulations were developed. The method-A is based on the condensation reaction of DNV forming an orange-red colored Schiff's base of maximum absorption peak (λ max) at 444 nm with sodium 1,2-naphthaquinone-4-sulfonate (NQS) in an alkaline medium. The dimethoxy benzene nucleus of brucine is attacked by IO4- with the formation of O-quinone (Bruci quinone) which in turn undergoes nucleophilic attack on the most electron rich position of the coupler i.e., proton bearing amino group (primary amine of DNV), to give 1-mono substituted Bruci quinone derivative. The reaction mechanism in both methods were discussed. The absorbance of colored complex is found at 511nm. Beer's law is obeyed in the concentration range 10-60 μg/ml, 50-300 μg/ml, the M.. Read More»

    Abstract HTML PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry